Center for Analytical Ultracentrifugation of Macromolecular Assemblies (CAUMA)


The Center for Analytical Ultracentrifugation of Macromolecular Assemblies (CAUMA) provides analytical ultracentrifugation (AUC) service for local and national investigators. Research projects conducted at CAUMA include the study of biological macromolecules, nanoparticles, and material science applications. For each study, we assist the investigator by developing a custom experimental design, performing the data acquisition, and by analyzing the resulting data using the popular UltraScan software, which provides unsurpassed resolution and accuracy. We also offer training on our AUC instruments, and teach a workshop on AUC data analysis with UltraScan.

AUC is a first principle separation method. It allows the investigator to perform all studies in a physiological solution state, where ionic strength, pH, solute concentration, buffer conditions, temperature, etc. can be modulated to investigate dynamic effects in the experimental system, and to replicate physiological conditions as closely as possible. AUC does not require any standards and provides composition information by resolving all dissolved solutes into size, shape or density distributions. Studies performed at CAUMA include, but are not limited to, research into protein/DNA/small molecule interactions, oligomerization of proteins, aggregation studies, composition analysis, particle sizing, anisotropy determination, particle density measurement, drug interactions, molecular weight determination, and macromolecular assembly.

CAUMA is a component laboratory of the UTHSCSA Center for Macromolecular Interactions (CMMI) located in the Department of Biochemistry and is a Shared Resource for The Cancer Therapy and Research Center (CTRC). AUC research studies conducted at CAUMA include academic collaborations and industry fee-for-service projects. If required, a non-disclosure agreement can be established. We pride ourselves in offering service of exceptional quality and meeting the highest standard.